Invokamet Lawsuit Information
Monday May 4, 2026 — The U.S. Food and Drug Administration recently issued new safety warnings regarding the diabetes drug Invokamet.
Invokamet (canagliflozin + metformin) is in a class of medications called sodium-glucose cotransporter-2 (SGLT2) inhibitors.
Drugs in this class have been linked to serious side effects, including:
- Amputations of the leg, foot, and toe
- Diabetic ketoacidosis (DKA)
- Acute kidney injury
- Urosepsis
If you or a loved one suffered injuries, you may have grounds to file an Invokamet lawsuit for compensation.
Invokamet and Amputations
In May 2017, the label for Invokamet was updated to include the FDA’s strongest “Black Box Warning” to caution patients about an increased risk of leg and foot amputations associated with use of the drug. The final results from two clinical trials showed that patients treated with Invokamet were twice as likely to suffer amputations when compared to nonusers.
As the FDA Safety Alert describes, while amputations of the toe and middle of the foot were most common, patients also experienced amputations of the leg both below and above the knee. Further, some patients in the study endured amputations involving both limbs. The rate of amputation injuries was equivalent to 5.9 out of every 1,000 patients.
Invokamet and Ketoacidosis
The FDA issued a prior safety warning in June 2016 regarding a heightened risk of ketoacidosis in patients using Invokamet and other SGLT2 inhibitors.
The FDA had identified 73 cases of diabetic ketoacidosis (or DKA) and 19 cases of blood and kidney infections over a two-year review period, as well as additional unreported cases.
The agency noted that DKA poses a particular risk because blood glucose levels may appear normal when tested, resulting in delayed diagnosis and treatment.
Lawsuits allege the drug manufacturer was aware of these life-threatening Invokamet side effects prior to the FDA review yet continually failed to warn doctors and patients of the dangers.
Invokamet Class Action Not Formed
Despite widespread use of the drug, an Invokamet class action lawsuit has not been formed on behalf of victims of amputation, ketoacidosis, kidney infection, or other personal injuries.
Instead, each patient must file a separate lawsuit and litigate their claim individually in the appropriate state or federal court.
This means you will need an attorney to represent you and guide you step-by-step through your individual case.
This also means you can pursue an Invokamet settlement for medical expenses, pain and suffering, lost earnings, and other legal damages you personally experienced.
Consult Our Invokamet Lawyers to Get Started
The first step in any case is to consult a knowledgeable Invokamet lawyer about your potential claim.
Our firm has dedicated over 25 years to representing patients in complex pharmaceutical litigation and we provide all consultations at no cost and with no obligation.
Reach our experienced Invokament lawyers by phone or online at any time to learn how we can help.